Highlands Park will look to end their winless streak in the Absa Premiership when they host Ajax Cape Town on 14 December 2016, kick-off at 19h30.
Highlands have gone 11 league matches without a win after they drew 1-1 at home to Bloemfontein Celtic on December 7.
The Tembisa-based side has claimed six points from as many home matches this season.
The Lions of the North are placed 15th on the Absa Premiership log with nine points from 12 matches.
Ajax racked up a third successive league win when they defeated Golden Arrows 1-0 at home on December 3.
The Cape Town side has claimed seven points from as many home matches this season.
The Urban Warriors are placed 11th on the Absa Premiership log with 12 points from as many matches.
This will be the first official league clash between Highlands Park and Ajax Cape Town.